Dexamethasone-modified ; で処置された
Finally, mass spectroscopy showed peaks at: 393.1, 355.2 147.1 m/z. The peak at 393.1 m/z is the peak for dexamethasone as its molecular weight is 392.46 m/z.
Dexamethasone-treated ; によって引き起こされる
Dexamethasone was first by in 1957. It was introduced for medical use in 1958.
デキサメタゾンの内服の方法には様々なやり方がありますが、慶應義塾大学病院では一晩法を採用しています。一晩法では、深夜23時に低用量の場合はデカドロン®1mg（2錠）、高用量の場合は8mg（16錠）を内服していただきます。そして、翌朝の8時～9時頃に血液検査を行い、コルチゾール濃度が低下するかどうかを検査します。入院中にこの検査を行う場合は、同時に蓄尿（ちくにょう）検査（24時間に排尿した尿をすべてバッグに貯める検査）を行って、尿中のコルチゾール濃度を参考にすることもあります。
Dexa methasoneの意味・使い方・読み方 | Weblio英和辞書
副腎におけるコルチゾールは、下垂体（かすいたい）から分泌される副腎皮質刺激ホルモン（ACTH）の指令に従って作られています。そして、ACTHとコルチゾールは早朝から午前中にかけて高値ですが、夕方から夜間は低値となり1日の中でも時間による変動（日内変動）があります。本検査でデカドロン®を内服すると、翌朝の血液中のACTH濃度は正常の場合にはほぼ完全に低下して、副腎への指令がなくなるために、副腎で作られるコルチゾール濃度も非常に低い値となります。しかし、クッシング症候群では、デカドロン®によりACTHを低下させても、副腎腫瘍からは依然としてコルチゾールが作られるために、翌朝の血中コルチゾール濃度が高い値となることで診断しています。
正常な低下反応の判定は、低用量の場合はコルチゾール濃度＜3μg/dl、高用量の場合はコルチゾール濃度＜1μg/dlで低下反応あり（正常）と判定します。ただし、クッシング症候群の最終的な判定は他の検査も踏まえて総合的に決定します。
DEXAMETHASONE | 意味, Cambridge 英語辞書での定義
In chemistry, is used to analyze products of reactions. To understand if dexamethasone is synthesized from a reaction, spectroscopy must be taken and compared to the literature spectrum. There are multiple spectroscopy analyses that can be taken including , , , , and
On 16 June 2020, the announced preliminary results stating that dexamethasone improves survival rates of hospitalized patients with receiving oxygen or on a . Benefits were only observed in patients requiring respiratory support; those who did not require breathing support saw a worse survival rate than the control group, although the difference may have been due to chance.A preprint containing the full dataset was published on 22 June 2020, and demand for dexamethasone surged after the publication of the preprint. The preliminary report was published in on 18 July 2020. The final report was published in February 2021.
デキサメタゾン（dexamethasone） とは？ 意味・読み方・使い方
To synthesize dexamethasone, 16β-methylprednisolone acetate is to the 9,11-dehydro . This is then reacted with a source of , such as basic , to form the 9α-bromo-11β-hydrin derivative, which is then ring-closed to an epoxide. A ring-opening reaction with in gives dexamethasone.[]
The (WHO) states that dexamethasone should be reserved for seriously ill and critical patients receiving COVID-19 treatment in a hospital setting, and the WHO Director-General stated that "WHO emphasizes that dexamethasone should only be used for patients with severe or critical disease, under close clinical supervision. There is no evidence this drug works for patients with mild disease or as a preventative measure, and it could cause harm." In July 2020, the WHO stated they were in the process of updating treatment guidelines to include dexamethasone or other steroids. In September 2020, the WHO released updated guidance on using corticosteroids for COVID-19.
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Dexamethasone poorly penetrates the into the due to binding to . However, higher doses of dexamethasone override the export capacity of P-glycoprotein and enter the brain to produce central activation of GRs. In conjunction with the suppression of endogenous corticosteroids by dexamethasone, this results in skewed ratios of activation of peripheral versus central GRs as well as skewed ratios of activation of GRs versus MRs when compared to non- corticosteroids. These differences can have significant clinical relevance.
デカドロン錠0.5mgの基本情報(副作用・効果効能・電子 ..
The activation of the GR by dexamethasone results in suppression of the (HPA axis) and of production of endogenous corticosteroids by the , thereby reducing circulating endogenous concentrations of corticosteroids like cortisol and .
デキサメタゾン 11107-64 100MG ナカライテスク株式会社
In July 2020, the (EMA) started reviewing results from the RECOVERY study arm that involved the use of dexamethasone in the treatment of patients with COVID-19 admitted to the hospital to provide an opinion on the results and in particular the potential use of dexamethasone for the treatment of adults with COVID-19. In September 2020, the EMA received an application for marketing authorization of dexamethasone for COVID-19.
dexamethasone – 日本語への翻訳 – 英語の例文
As a glucocorticoid, dexamethasone is an of the (GR). It is highly for the GR over the (MR), and in relation to this, has minimal activity. This is in contrast to corticosteroids like , which bind to and activate both the GR and the MR. Dexamethasone is 25 times more than (cortisol) as a glucocorticoid. Its (Ki) for the GR was about 1.2nM in one study.
デキサメタゾンリン酸ナトリウム dexamethasone sodium phosphate〔【略】DSP〕 ..
Dexamethasone is inexpensive. In the United States a month of medication is typically priced less than . In India, a course of treatment for preterm labor is about . The drug is available in most areas of the world.
デキサメタゾンの毒性試験と結果の概要 （評価書：JECFA 1994）
デキサメタゾン抑制試験は、クッシング症候群（「」の項参照）が疑われた場合に行う検査で、デキサメタゾン（商品名：デカドロン）は副腎（腎臓の上にある小さな内分泌臓器）で作られるコルチゾールの作用を強力にした内服薬です。
デキサメタゾンプロピオン酸エステルクリーム 英語：dexamethasone propionate
Dexamethasone is given in , causing weight gain aimed at making them appear older and healthier to customers and police.
臨床試験では、糖質コルチコイド受容体に結合する強力な抗炎症薬であるデキサメタゾン（dexamethasone ..
The exact incidence of the adverse effects of dexamethasone is not available, hence estimates have been made as to the incidence of the adverse effects below based on the adverse effects of related corticosteroids and on available documentation on dexamethasone.
デキサメタゾン（dexamethasone）、リン酸デキサメタゾン
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ラット（Crl:SD(CD)BR 系、雄 7 匹）に[1,2,4-3H]標識デキサメタゾンを単回筋肉内投
The combination of dexamethasone and a such as is more effective than a 5-HT3 receptor antagonist alone in preventing postoperative nausea and vomiting.